An 11-year old girl named Riley Andersen moves from Minnesota to San Francisco. She thought everything would be great, but started having doubts after seeing her new house and other aspects of the town. Her emotions, Joy, Sadness, Anger, Disgust, and Fear, try their best to make Riley happy. When it’s Riley’s first day of school, Joy and Sadness are ejected out of the Headquarters through a series of mishaps. Now it’s up to Anger, Disgust, and Fear to make Riley happy until they return, but things quickly go downhill.